They haven't played against each other since the Cotton Bowl on Jan. 3, 2014.
But on New Year's Eve, the Oklahoma State football team will take on former Big 12 opponent Missouri in Memphis, Tennessee.
The Cowboys will face the No. 23 Tigers in the 60th annual AutoZone Liberty Bowl Classic, the bowl's representatives announced Sunday. The game is set for 2:45 p.m. on Dec. 31 in Liberty Bowl Memorial Stadium.
The Tigers ended the regular season 8-4 with a 4-4 record in the Southeastern Conference.
"They've (the Tigers) done great things, come a long way," Mike Gundy, OSU's coach, said in a teleconference. "We'll have our hands full, but I'm looking forward to a good game."
Missouri defeated OSU 41-31 in the 2014 Cotton Bowl matchup. The Tigers hold a 29-23 record against the Cowboys.
"We had a lot of good times back in the old Big 8 days and then even in the Big 12," Gundy said. "I've made that pretty obvious that I hated to see when that league broke up with Nebraska and Missouri and (Texas) A&M departing, so I think it's pretty cool that we get to play a team that we've been accustomed to playing for a long, long time."
Along with history as conference rivals, there are other connections between OSU and Missouri. Baron Odom, an OSU redshirt freshman, is the nephew of Barry Odom, Missouri's coach. Josh Henson, the Cowboys' offensive line coach and a former offensive lineman at OSU, once served as the Tigers' offensive coordinator.
OSU finished the regular season 6-6, and each of the six losses were against a Big 12 opponent.
Most recently, the Cowboys dropped a 31-24 game to Texas Christian University in Amon G. Carter Stadium. That happened one weekend after OSU secured bowl eligibility with a 45-41 home victory against West Virginia.
This season, OSU averaged 38.42 points per game, 192.1 rushing yards per game and 307.92 passing yards per game.
Tickets to the Liberty Bowl are available on Ticketmaster.com.
The Cowboys are one of seven Big 12 teams to earn a slot in a bowl. No. 4 Oklahoma will face No. 1 Alabama on Dec. 29 in the Orange Bowl for a College Football Playoff game.
No. 15 Texas will meet No. 5 Georgia on Jan. 1 in the Allstate Sugar Bowl.
No. 16 West Virginia will match up with No. 20 Syracuse on Dec. 28 in the Camping World Bowl, in which the Cowboys appeared one season ago.
No. 24 Iowa State will face Washington State on Dec. 28 in the Alamo Bowl.
Baylor will stay in its home state as it takes on Vanderbilt on Dec. 27 in the Texas Bowl, and TCU will play against California on Dec. 26 in the Cheez-It Bowl.